The name of Usigni is a deformation of "usina,a word used to indicate factory.
The settlement consists of buildings of two or three floors and it's compact in the middle part. Around the middle of the seventeenth century the Cardinal Fausto Poli supported the building of the church of San Salvatore and the Cardinal's Palace (Palazzo Poli). The Cardinal Fausto Poli was a native of the place and very influential in the court of Pope Urban VIII.
The upstream settlement is very sparse. Especially during the summer the village is repopulated when the local families come back for in close contact with the magical nature of the place. This happens in many other small village of the Nera Valley