Francis himself, founded one of the first communities of Friars Minor here. The façade still boasts its Romanesque doorway, while the rose window was destroyed to make way for a window in the 16th century. The layout of the church is a Latin Cross with a single nave.
Inside you'll find a large painting on wood depicting the Madonna and Child with Saints (1508) by Pinturicchio and commissioned by Gentile Baglioni. The crucifix on wood behind the 14th-century main altar is by an unknown local pupil of Giotto (14th century).