The Church of Saints Gervasius and Protasius, which is the cathedral of Città della Pieve, is located where Piazza Gramsci and Piazza Plebiscito, the town’s central squares, meet. It stands on the site of a primitive parish church dedicated to the Martyred Gervasius and Protasius, the two patron saints of the town. 

The church has undergone various changes over time: it was completely renovated in the 16th century with a rededication in 1584, then again transformed following its elevation first to Collegiate Church and then to Cathedral. In 1714, bone fragments of the two martyrs arrived in Città della Pieve from Milan, and from Naples, a small ampulla of fluid blood, traditionally attributed to the two brothers.

The original construction, built on the remains of earlier civil buildings dating back to Etruscan-Roman times, dates back to the 8th century AD; the church was then rebuilt in the 13th century, and from this period remains the underground area, possibly a crypt, part of the façade, on which we can see a series of Gothic arches, and the lower part of the bell tower with a succession of mullioned, three- and four-light windows.

In the 16th century, the church underwent a new renovation: the floor was raised and the external staircase was built; in 1574, the apse was rebuilt. Its current form, with a single nave in the shape of a Latin cross, with the addition of the large side chapels (three on each side) and the bell tower flanking the building, dates back to the 16th-17th centuries, when the church became the cathedral of the diocese. The truss roof collapsed in 1667 and was replaced with a brick vault in 1679.